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C. elegans has proved to be a particularly useful mannequin organism for mode of action studies, nonetheless, the opportunity it presents for drug discovery has arguably been under-utilised (see ‘Bridging where to buy generic stromectol online no prescription the Divide’; Worm Breeder's Gazette Volume 19, Number 4). An extra concern is the threat to crops from plant parasitic nematodes, as presently accessible nematicides are progressively withdrawn from use as a consequence of their environmental affect. Recently, ahead genetic screens have offered additional insight into the mechanism by which emodepside exerts its inhibitory motion on C. elegans muscle. Strains carrying functional null alleles of slo-1 are extremely resistant to the inhibitory effects of emodepside on locomotion and feeding.


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